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. 1995;427(2):119-24.
doi: 10.1007/BF00196515.

Gastric adenoma-carcinoma sequence with special reference to p53 and Ki-ras gene alterations

S Sakurai  1 , T Sano, A Maeshima, K Kashiwabara, T Oyama, T Fukuda, T Nakajima
Affiliations

Gastric adenoma-carcinoma sequence with special reference to p53 and Ki-ras gene alterations

S Sakurai et al. Virchows Arch. 1995.

Abstract

With the aim of detecting the timing of p53 and Ki-ras gene alterations in the gastric adenoma-carcinoma sequence, 19 early gastric adenocarcinomas arising from adenomas were studied. Immunohistochemically, 5 adenocarcinomas were positive for p53; 3 focally and 2 diffusely. The p53 point mutations were detected in a focal area with p53 immunoreactivity in 2 of the 5 p53-positive adenocarcinomas. This indicated that p53 point mutations may play a less crucial part in malignant conversion of adenoma to adenocarcinoma in the stomach than in the colon. No Ki-ras gene mutations at codons 12 and 13 were detected in any lesion. These results suggest that the adenoma-carcinoma sequence in the stomach has a different mechanism from that in the colon.

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References

    1. Jpn J Cancer Res. 1991 Mar;82(3):308-14 - PubMed
    1. Cancer Res. 1990 Dec 1;50(23):7717-22 - PubMed
    1. J Cancer Res Clin Oncol. 1993;119(5):265-72 - PubMed
    1. Cancer Res. 1990 Nov 15;50(22):7166-73 - PubMed
    1. Jpn J Clin Oncol. 1992 Aug;22(4):225-31 - PubMed

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