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. 1979 Jan;25(1):103-7.
doi: 10.1002/cpt1979251103.

Altered drug binding due to the use of indwelling heparinized cannulas (heparin lock) for sampling

M Wood, D G Shand, A J Wood

Altered drug binding due to the use of indwelling heparinized cannulas (heparin lock) for sampling

M Wood et al. Clin Pharmacol Ther. 1979 Jan.

Abstract

The effect of the use of the so-called heparin lock for blood sampling on the binding of propranolol has been studied and a cumulative dose-response curve to heparin constructed. The use of this method of blood sampling introduced considerable artifactual changes into the measurement of propranolol's plasma binding. The free fraction rose from 9.9% to 13.4% after only 50 U of heparin was used to flush the cannula. The increase in the free fraction of propranolol showed excellent correlation with the increase in free fatty acid levels (p less than 0.001, r = 0.996). The importance of ensuring that sampling techniques do not introduce artifactual changes in pharmacokinetic studies is emphasized.

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