[Toxicity dynamics of anionic dyes in the air of a work place and long-term effects after absorption through the skin]

Abstract

The study covered 10 types of anion dyes for leather: Crimson 4RT, Gray M, Solid Blue, Red 8S, Black N, Brown 46, 673, 911, 551, 557. According to LD50 criterion they all were assigned to IV jeopardy class. It instilled per os 30 times, the chemicals induced mild hemotoxic effect similar to that of methemoglobin-formers, in half of the cases affected gonads. Allergic and local irritating skin effects were unusual. Solid Blue and Crimson 4RT dyes were subjected to inhalation trials. Limcf for those two equal 51.8 and 38.0 mg/m3 respectively Limch--8.3 and 7.1 mg/m3, measured through changes in red blood parameters, behavioral response and other reactions. With consideration of Limch, toxicity for gonads and embryos, mutagenicity, the authors justified the MAC for Crimson 4RT dye in the air of workplace--1 mg/m3 (II jeopardy class), for Solid Blue dye--5 mg/m3 (III jeopardy class).