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. 1995 Jul;2(4):503-5.
doi: 10.1128/cdli.2.4.503-505.1995.

Immunomodulatory effects of alpha interferon and thymostimulin in patients with neoplasias

I Munno  1 , M Marinaro, A Gesario, B Cannuscio, Y Michel, E Paulling
Affiliations

Immunomodulatory effects of alpha interferon and thymostimulin in patients with neoplasias

I Munno et al. Clin Diagn Lab Immunol. 1995 Jul.

Abstract

In this report, we have evaluated the immunological effects following administration of alpha interferon (IFN-alpha) in combination with thymostimulin (TP-1), as well as of IFN-alpha and TP-1 alone in patients with neoplasias who underwent surgery and were subsequently treated with conventional chemotherapy. Data suggest that the combination of IFN-alpha and TP-1 is the most effective in the up-regulation of some immune parameters such as the CD4(+)-CD8+ cell-dependent antibacterial activity. Since this immune function plays an important role in the host protection against different targets such as invading microorganisms and/or neoplastic cells, the administration of TP-1-IFN-alpha is advisable for patients with neoplasias under chemotherapy.

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