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. 1979 Jan;68(1):112-4.
doi: 10.1002/jps.2600680139.

Enantiomeric purity of naproxen by liquid chromatographic analysis of its diastereomeric octyl esters

D M Johnson, A Reuter, J M Collins, G F Thompson

Enantiomeric purity of naproxen by liquid chromatographic analysis of its diastereomeric octyl esters

D M Johnson et al. J Pharm Sci. 1979 Jan.

Abstract

A sensitive and specific analytical method was developed to determine the enantiomeric purity of naproxen. A simple derivatization of naproxen with (S)-(+)-2-octanol proceeded quantitatively and gave a mixture of diastereomeric esters displaying baseline separation on liquid chromatography. The ratio of these esters was the same as the ratio of enantiomers present in naproxen samples assayed. Reproducibility of the method was excellent.

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