[Lipid peroxidation in plasma and the activity of superoxide dismutase (SOD) in pregnant women with premature rupture of membrane]

Abstract

To investigate the condition of lipid peroxidation and antioxidation in premature rupture of membrane (PROM), we selected 50 women with PROM, without significant inducing factors, as study group, and 116 healthy and uneventful gestational age pregnant women as controls. Blood samples were collected from the maternal and umbilical cord vein. The concentration of plasma malondialdehyde (MDA) and the activity of erythrocyte superoxide dismutase (SOD), selenium glutathione peroxidase (SeGSH-Px) were determined. The results showed that the plasma concentrations of MDA in the maternal and umbilical cord vein were significantly higher in the PROM group than in the control group (P < 0.01), and the activity of erythrocyte SOD and SeGSH-Px were significantly lower in the PROM group than in the control group (P < 0.01). The levels in plasma of MDA and SeGSH-Px in erythrocyte were significantly higher in the maternal blood than in the umbilical cord blood, but the SOD activity was significantly lower. A positive correlation of MDA concentration in plasma was found both in the maternal and umbilical cord veins (P < 0.01). It is suggested that lipid peroxidation improved may be one of the factors of PROM induced, and one of the factors of other related diseases induced by PROM.