doi: 10.1159/000232059.
IgE-induced changes in human basophil cyclic AMP levels
- PMID: 75852
- DOI: 10.1159/000232059
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IgE-induced changes in human basophil cyclic AMP levels
Int Arch Allergy Appl Immunol.
1978.
Abstract
We studied a unique patient with 77% basophils, not different from normal by a number of criteria, in order to measure the changes in cyclic AMP level associated with IgE-mediated histamine release. In accordance with previous hypothesis and circumstantial evidence, anti-IgE challenge led to a significant fall in the cyclic AMP level which preceded histamine release.
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