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. 1978;56(5):473-8.
doi: 10.1159/000232059.

IgE-induced changes in human basophil cyclic AMP levels

L M Lichtenstein, A K Sobotka, F J Malveaux, E Gillespie

IgE-induced changes in human basophil cyclic AMP levels

L M Lichtenstein et al. Int Arch Allergy Appl Immunol. 1978.

Abstract

We studied a unique patient with 77% basophils, not different from normal by a number of criteria, in order to measure the changes in cyclic AMP level associated with IgE-mediated histamine release. In accordance with previous hypothesis and circumstantial evidence, anti-IgE challenge led to a significant fall in the cyclic AMP level which preceded histamine release.

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