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. 1995 Nov 17;83(4):539-45.
doi: 10.1016/0092-8674(95)90093-4.

The stabilization of repetitive tracts of DNA by variant repeats requires a functional DNA mismatch repair system

S M Heale  1 , T D Petes
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Free article

The stabilization of repetitive tracts of DNA by variant repeats requires a functional DNA mismatch repair system

S M Heale et al. Cell. .
Free article

Erratum in

  • Cell 1996 May 31;85(5):following 779

Abstract

Simple repetitive tracts of DNA are unstable in all organisms thus far examined. In the yeast S. cerevisiae, we show that a 51 bp poly(GT) tract alters length at a rate of about 10(-5) per cell division. Insertion of a single variant repeat (either AT or CT) into the middle of the poly(GT) tract results in 100-fold stabilization. This stabilization requires the DNA mismatch repair system. Alterations within tracts with variant repeats occur more frequently on one side of the interruption than on the other. The stabilizing effects of variant repeats and polarity of repeat alterations have also been observed in trinucleotide repeats associated with certain human diseases.

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