Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1995;48(3-4):225-8.
doi: 10.1007/BF00198302.

The characteristics of the inhibition of serum cholinesterase by metoclopramide

S G Graham  1 , A W Crossley
Affiliations

The characteristics of the inhibition of serum cholinesterase by metoclopramide

S G Graham et al. Eur J Clin Pharmacol. 1995.

Abstract

The inhibition of serum cholinesterase by metoclopramide has been previously characterised in vitro at high dilution of the enzyme. We examined the effect of varying enzyme dilution over a range of 1000 fold dilution, and assay temperature at 25 degrees C and 37 degrees C on the fractional inhibition of enzyme activity by metoclopramide. Neither enzyme concentration nor reaction temperature affected this fractional inhibition. Concentrations of metoclopramide producing 50% inhibition of enzyme activity were in the range 1.0-1.9 x 10(-6) M. Lineweaver-Burk analysis of the enzyme reaction suggests that the pattern of this inhibition is competitive.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Anaesthesia. 1972 Jan;27(1):90-1 - PubMed
    1. Clin Chem. 1978 Oct;24(10):1762-6 - PubMed
    1. Br J Anaesth. 1990 Aug;65(2):220-4 - PubMed
    1. Br J Clin Pharmacol. 1980 Apr;9(4):371-7 - PubMed
    1. Can J Anaesth. 1987 Nov;34(6):579-81 - PubMed

LinkOut - more resources