Ovarian volume: a novel outcome predictor for assisted reproduction

Abstract

Objective: To determine the potential of ovarian volume as a predictor of assisted reproduction outcomes.

Design: Retrospective chart review.

Setting: University-based assisted reproduction program.

Patients: One hundred eighty-eight women initiating their first cycle of assisted reproduction.

Interventions: None.

Main outcome measures: Pretreatment transvaginal ultrasound ovarian measurements were compared with subsequent ovulation induction parameters (peak E2, numbers of oocytes, and embryos) and cycle outcome (cancellation and pregnancy).

Result: Total ovarian volume and volume of the smallest ovary were significant variables predicting peak E2 and numbers of oocytes and embryos. Total ovarian volume was a predictor of cycle cancellation and volume of the smallest ovary a predictor of clinical pregnancy. Large ovarian volumes are associated with good assisted reproductive technology outcomes whereas small ovarian volumes are associated with poor outcomes.

Conclusion: Beyond maternal age, total ovarian volume, and volume of the smallest ovary are significant predictors of the success of assisted reproductive techniques.