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. 1995 Oct 3;163(2):329-30.
doi: 10.1016/0378-1119(95)00420-b.

Identification and cloning of the G3B cDNA encoding a 3' segment of a protein binding to GATA-3

V S Shapiro  1 , P Lee, A Winoto
Affiliations

Identification and cloning of the G3B cDNA encoding a 3' segment of a protein binding to GATA-3

V S Shapiro et al. Gene. .

Abstract

The transcription factor GATA-3 contributes to the expression of several genes critical for T-cell function and development, including the T-cell receptor alpha and beta chains. We report here the isolation of a human cDNA clone which encodes a 3' segment of a novel protein with three zinc fingers. This protein, which we termed G3B, can interact with GATA-3 in vitro. Its mRNA is expressed in T and B cells. Thus, G3B may represent a potential regulator of GATA-3 function.

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