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. 1995 Nov;63(11):4515-8.
doi: 10.1128/iai.63.11.4515-4518.1995.

Reduced virulence of Candida albicans mutants affected in multidrug resistance

J M Becker  1 , L K Henry, W Jiang, Y Koltin
Affiliations

Reduced virulence of Candida albicans mutants affected in multidrug resistance

J M Becker et al. Infect Immun. 1995 Nov.

Abstract

Disruption of a multidrug resistance gene (CaMDR1) in Candida albicans resulted in mutant strains that colonized mouse kidneys to very high levels but were markedly reduced in their virulence. No obvious differences in several properties related to colonization and dissemination were noted among MDR+ or mdr- strains. These results suggest that specific fungal efflux pumps play a role in fungal pathogenicity.

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