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. 1995 Nov;63(11):4540-2.
doi: 10.1128/iai.63.11.4540-4542.1995.

Regulation of virulence by environmental signals in group A streptococci: influence of osmolarity, temperature, gas exchange, and iron limitation on emm transcription

K S McIver  1 , A S Heath, J R Scott
Affiliations

Regulation of virulence by environmental signals in group A streptococci: influence of osmolarity, temperature, gas exchange, and iron limitation on emm transcription

K S McIver et al. Infect Immun. 1995 Nov.

Abstract

Transcription of the gene encoding the antiphagocytic M protein (emm) of the group A streptococci has been shown to be regulated by CO2 (M. G. Caparon, R. T. Geist, J. Perez-Casal, and J. R. Scott, J. Bacteriol. 174:5693-5701, 1992). We tested the influence of additional environmental growth conditions on emm expression. Increased osmolarity, low temperature, growth with free exchange of gasses, or the restricted availability of iron resulted in decreased transcription from the emm promoter.

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