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Review
. 1995 May;16(4):217-22.
doi: 10.1007/BF02282992.

Antiepileptic drugs and mechanisms of epileptogenesis. A review

R Mutani  1 , R Cantello, M Gianelli, C Civardi
Affiliations
Review

Antiepileptic drugs and mechanisms of epileptogenesis. A review

R Mutani et al. Ital J Neurol Sci. 1995 May.

Abstract

This paper analyzes the effect of conventional (phenobarbital, phenytoin, carbamazepine, ethosuximide, valproate) and some novel (vigabatrin, lamotrigine, felbamate) AEDs on some basic mechanisms involved in focal and/or generalized epileptogenesis (Na+ voltage-dependent channels and sustained repetitive firing, L-, N-, and T-type Ca2+ currents, GABA-mediated inhibition, Glu/Asp-mediated excitation, after-hyperpolarization). According to this analysis, AEDs can be divided into two main categories, those with only one specific action and those with multiple actions. A speculative correlation is proposed between AED effects on the mechanism of epileptogenesis and their known clinical effect on seizures.

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References

    1. Science. 1987 Jul 10;237(4811):157-64 - PubMed
    1. Eur J Pharmacol. 1983 Mar 18;88(1):1-9 - PubMed
    1. Epilepsia. 1992 May-Jun;33(3):564-72 - PubMed
    1. Lancet. 1992 Jun 6;339(8806):1397-400 - PubMed
    1. Epilepsia. 1989 May-Jun;30(3):286-94 - PubMed