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Review
. 1995 Jun;10(6):1563-5.
doi: 10.1093/humrep/10.6.1563.

Aetiology of age-associated aneuploidy: a mechanism based on the 'free radical theory of ageing'

J J Tarín  1
Affiliations
Review

Aetiology of age-associated aneuploidy: a mechanism based on the 'free radical theory of ageing'

J J Tarín. Hum Reprod. 1995 Jun.

Abstract

A general model is put forward to explain the mechanism by which age-associated aneuploidies are produced. This is based on the free radical theory of ageing, which assumes a rise in oxidative stress with age. It is proposed that determination of indicators of oxidative stress in oocytes from various sources could be a first step in the testing of this hypothesis.

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