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. 1995 Nov 15;155(10):4529-33.

Human DNA-activated protein kinase (DNA-PK) is homologous to phosphatidylinositol kinases

V P Poltoratsky  1 , X Shi, J D York, M R Lieber, T H Carter
Affiliations
  • PMID: 7594449

Human DNA-activated protein kinase (DNA-PK) is homologous to phosphatidylinositol kinases

V P Poltoratsky et al. J Immunol. .

Abstract

DNA-activated protein kinase (DNA-PK) is a serine/threonine protein kinase that interacts with a DNA end-binding heterodimeric protein, Ku, and is activated by double-stranded DNA. Genomic clones that contain the DNA-PK gene complement the murine scid defect, indicating that DNA-PK affects double-strand break repair and V(D)J recombination. Here we describe the cDNA sequence of the region that corresponds to about 100 kDa of C-terminal sequence of this large (> p350 kDa) protein. This region contains a kinase domain that has strong homology to phosphatidylinositol kinases.

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