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Clinical Trial
. 1995 May;71(835):284-6.
doi: 10.1136/pgmj.71.835.284.

Prophylactic use of fluconazole in neutropenic cancer patients

K Yamaç  1 , E Senol, R Haznedar
Affiliations
Clinical Trial

Prophylactic use of fluconazole in neutropenic cancer patients

K Yamaç et al. Postgrad Med J. 1995 May.

Abstract

This study was carried out on 70 patients with haematological or solid malignancies who were receiving chemotherapy and/or radiotherapy. Forty-one patients were randomly assigned to receive fluconazole, 400 mg/day, while they were neutropenic. Systemic fungal infection developed in four of the 41 patients (9%) receiving prophylaxis in comparison to nine of 29 patients (31%) not receiving prophylaxis. The incidence of systemic fungal infection was significantly different between the groups receiving prophylaxis and those not receiving it (p < 0.05). Fluconazole was found to be effective for preventing systemic fungal infections in neutropenic patients with cancer.

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