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Review
. 1995 Aug 1;123(3):216-24.
doi: 10.7326/0003-4819-123-3-199508010-00009.

Interferon-gamma in the management of infectious diseases

J I Gallin  1 , J M Farber, S M Holland, T B Nutman
Affiliations
Review

Interferon-gamma in the management of infectious diseases

J I Gallin et al. Ann Intern Med. .

Abstract

Interferon-gamma has pleiotropic adjuvant effects on host defenses. These effects have made interferon-gamma particularly useful for enhancing host defenses in patients with chronic granulomatous disease of childhood and thus for reducing the incidence of life-threatening infections in these patients. Increasingly, data suggest that interferon-gamma will be useful for treating infections characterized by intracellular persistence in macrophages, such as toxoplasmosis, leishmaniasis, and mycobacteriosis. Interferon-gamma is emerging as an important cytokine for use in the treatment of infectious diseases.

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