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Case Reports
. 1995 Jul;121(7):778-82.
doi: 10.1001/archotol.1995.01890070064014.

Amyloidosis of the head and neck. A clinicopathologic study of the UCLA experience, 1955-1991

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Case Reports

Amyloidosis of the head and neck. A clinicopathologic study of the UCLA experience, 1955-1991

M M Kerner et al. Arch Otolaryngol Head Neck Surg. 1995 Jul.

Abstract

Objective: To characterize the otolaryngologic manifestations of amyloidosis; classify patients with amyloidosis by specific location and type of underlying disease; and compare disease presentation and long-term outcome in these patients.

Design: Retrospective review of biopsy specimens recorded as amyloidosis.

Setting: Tertiary care referral center serving a diverse patient base.

Patients: Of 141 patients with biopsy-verified amyloidosis who met the inclusion criterion for the study, 27 (19%) had head and neck manifestations.

Outcome measures: Good functional outcome and survival of patients with amyloidosis.

Results: The tongue was the most commonly affected site of the head and neck. Distinct differences exist in functional outcome and long-term survival in patients with the localized form of amyloidosis when compared with patients with systemic amyloidosis.

Conclusion: Because amyloidosis often affects the head and neck, otolaryngologists need to be familiar with this disease.

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