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Comparative Study
. 1995 Jun 9;1262(2-3):105-12.
doi: 10.1016/0167-4781(95)00059-p.

The genes for human brain factor 1 and 2, members of the fork head gene family, are clustered on chromosome 14q

S Wiese  1 , D B Murphy, A Schlung, P Burfeind, D Schmundt, V Schnülle, M G Mattei, U Thies
Affiliations
Comparative Study

The genes for human brain factor 1 and 2, members of the fork head gene family, are clustered on chromosome 14q

S Wiese et al. Biochim Biophys Acta. .

Abstract

Brain factor-1 (BF-1) is a member of the fork head gene family which shows expression restricted to the neurons of the developing telencephalon in rodents and man. We have isolated a second human gene (HBF-2), which is also strongly expressed in embryonic brain and has very high homology to both the rat and human brain factor-1 genes and the retroviral oncogene qin. The HBF-2 cDNA was isolated from a human fetal brain expression library and contains a putative open reading frame of 479 amino acids. The HBF-2 gene is strongly expressed in fetal brain and also with lower levels of expression in several adult tissues. At the genomic level the gene for HBF-1 contains an 500 bp intron situated between the DNA binding domain II and the fork head domain while that of HBF-2 is intronless. The two genes are clustered on human chromosome 14q11-13.

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