Review
doi: 10.1016/0300-9084(96)88102-8.
Cap binding complexes and cellular growth control
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- PMID: 7599274
- DOI: 10.1016/0300-9084(96)88102-8
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Review
Cap binding complexes and cellular growth control
Biochimie.
1995.
Abstract
The cap-binding complex eIF-4F plays a major role in the control of translation initiation, and overexpression of its limiting subunit, eIF-4E, leads to the deregulation of cellular growth. The recent cloning of eIF-4E binding proteins (4E-BPs) has uncovered a previously unsuspected pathway for the regulation of eIF-4E activity, through sequestration of eIF-4E as a complex with 4E-BPs.
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