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Review
. 1995 Apr;61(3):105-12.
doi: 10.1016/0925-5710(95)00361-u.

BCR/ABL signal transduction

T Tauchi  1 , H E Broxmeyer
Affiliations
Review

BCR/ABL signal transduction

T Tauchi et al. Int J Hematol. 1995 Apr.

Abstract

A strong association between the Philadelphia chromosome (Ph1) and chronic myelogenous leukemia (CML) suggests that the Ph1 translocation plays a significant role in pathogenesis of CML. For this reason, Ph1-positive leukemias have been well studied from the molecular, clinical and cell biological perspective. In this review article, intracellular signalling events involving BCR/ABL fusion gene products are discussed in the context of the role of the Ph1 chromosome in human leukemia.

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