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. 1979 Jan;37(1):104-8.
doi: 10.1128/aem.37.1.104-108.1979.

Production of antibody against T-2 toxin

F S Chu, S Grossman, R D Wei, C J Mirocha

Production of antibody against T-2 toxin

F S Chu et al. Appl Environ Microbiol. 1979 Jan.

Abstract

Antibody against T-2 toxin was obtained after immunization of rabbits with bovine serum albumin-T-2 hemisuccinate conjugate. The antibody had greatest binding efficiency for T-2 toxin, less efficiency for HT-2, and least for T-2 triol. Cross-reaction of antibody with neosolaniol, T-2 tetraol, and 8-acetyl-neosolaniol was very weak. Diacetoxyscirpenol, trichodermin, vomitoxin, and verrucarin A essentially gave no cross-reaction with the antibody. The sensitivity of the binding assay for T-2 toxin detection was in the range of 1 to 20 ng per assay. Detailed methods for the preparation of the conjugate and the production of immune serum and methods for antibody determination are described.

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References

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