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. 1995 Jun 14;51(6):612-5.
doi: 10.1007/BF02128754.

Long-lasting persistence of elevated sister-chromatid exchange frequencies induced by perinatal benzo(a)pyrene treatment in rat bone-marrow cells

P Igaz  1 , S Tóth, G Csaba
Affiliations

Long-lasting persistence of elevated sister-chromatid exchange frequencies induced by perinatal benzo(a)pyrene treatment in rat bone-marrow cells

P Igaz et al. Experientia. .

Abstract

In this work the possibility that a mutagenic factor acting in utero or in the perinatal period might lead to elevated mutagenic rates in bone-marrow cells after a considerable period of time was examined. An aromatic hydrocarbon, benzo(a)pyrene was used as the test substance. Benzo(a)pyrene treatments resulted in significantly higher sister-chromatid exchange (SCE)-frequencies in both fetal and neonatal groups in both sexes, even four months after exposure. In a second experiment we examined whether mutagenic exposure suffered in utero could make the individual more susceptible to mutagenic effects in adulthood. Preliminary results indicate that such a possibility could exist.

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