Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1995 May 19;157(1-2):163-4.
doi: 10.1016/0378-1119(94)00624-2.

Disruption of the target G-C base-pair by the HhaI methyltransferase

S Klimasauskas  1 , R J Roberts
Affiliations
Comparative Study

Disruption of the target G-C base-pair by the HhaI methyltransferase

S Klimasauskas et al. Gene. .

Abstract

HhaI MTase binds DNA duplexes containing mismatches at the target base position with higher affinity than that observed for the canonical substrate. The stability of these MTase-DNA complexes inversely correlates with the strength of the base pair that is disrupted upon interaction. This finding may offer a general tool to detect other enzymes that flip bases out of the DNA helix.

PubMed Disclaimer

Publication types

LinkOut - more resources