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Case Reports
. 1995 Jul;96(1):65-9.
doi: 10.1007/BF00214188.

Familial reciprocal translocation t(17;19) (q11.2;q13.2) associated with neurofibromatosis type 1, including one patient with non-Hodgkin lymphoma and an additional t(14;20) in B lymphocytes

R Fahsold  1 , T Habash, U Trautmann, A Haustein, R A Pfeiffer
Affiliations
Case Reports

Familial reciprocal translocation t(17;19) (q11.2;q13.2) associated with neurofibromatosis type 1, including one patient with non-Hodgkin lymphoma and an additional t(14;20) in B lymphocytes

R Fahsold et al. Hum Genet. 1995 Jul.

Abstract

The cosegregation of a reciprocal translocation t(17;19) (q11.2;13.2) with neurofibromatosis type 1 in three generations suggested that the breakpoint on chromosome 17 involved the NF1 gene. In order to map the breakpoint, we analysed DNAs of patients using parts of the NF1 gene as probes. Southern analysis revealed that the chromosome 17 breakpoint lies within intron 23 of the NF1 gene. One of the patients of the family developed a non-Hodgkin lymphoma. An additional translocation t(14;20) (q32;13.1) in his B lymphocytes points to a gene on chromosome 20 that is juxtaposed to the IGH locus on 14q32, and that may be of relevance for the development of this tumor type.

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References

    1. Cell. 1990 Jul 13;62(1):187-92 - PubMed
    1. Am J Hum Genet. 1989 Jan;44(1):20-4 - PubMed
    1. N Engl J Med. 1994 Mar 3;330(9):597-601 - PubMed
    1. Genes Chromosomes Cancer. 1993 Aug;7(4):231-9 - PubMed
    1. Cytogenet Cell Genet. 1990;53(4):206-10 - PubMed

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