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. 1995 Jul 7;270(27):15923-5.
doi: 10.1074/jbc.270.27.15923.

Cyclin A links c-Myc to adhesion-independent cell proliferation

J F Barrett  1 , B C Lewis, A T Hoang, R J Alvarez Jr, C V Dang
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Free article

Cyclin A links c-Myc to adhesion-independent cell proliferation

J F Barrett et al. J Biol Chem. .
Free article

Abstract

Adhesion-independent growth is a neoplastic phenotype that is inducible in Rat 1a fibroblasts by enforced MYC expression. The c-Myc protein has been well characterized as a transcription factor, yet the molecular basis of c-Myc-induced neoplastic transformation has remained elusive. In this report, we demonstrate a link between ectopic MYC expression, deregulated cyclin A levels, and adhesion-independent growth.

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