Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1979 Jan;26(1):22-5.
doi: 10.1007/BF03039448.

Glycopyrrolate and cardiac dysrhythmias in geriatric patients after reversal of neuromuscular blockade

S Muravchick, W D Owens, J A Felts

Glycopyrrolate and cardiac dysrhythmias in geriatric patients after reversal of neuromuscular blockade

S Muravchick et al. Can Anaesth Soc J. 1979 Jan.

Abstract

The increase in cardiac muscarinic activity following injection of anticholinesterases can be minimized by the long-acting anticholinergic drug glycopyrrolate. In a series of 50 patients 65 years of age or older who had received glycopyrrolate (0.88 +/- 0.15 mg) mixed with neostigmine (4.40 +/- 0.66 mg) or pyridostigmine (17.46 +/- 2.92 mg) to antagonize neuromuscular blockade, the incidence of new postoperative cardiac dysrhythmias was 16 per cent. All dysrhythmias occurred in patients with pre-existing cardiovascular disease. There was no statistically significant relationship between the incidence of cardiac dysrhythmias and the choice of anaesthetic technique or anticholinesterase drug.

PubMed Disclaimer

References

    1. J Pharmacol Exp Ther. 1957 Jun;120(2):215-28 - PubMed
    1. Am J Med. 1955 Nov;19(5):673-8 - PubMed
    1. Am J Med. 1955 Nov;19(5):737-9 - PubMed
    1. Anesthesiology. 1973 Nov;39(5):504-9 - PubMed
    1. Br J Anaesth. 1971 Nov;43(11):1066-74 - PubMed

MeSH terms