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. 1995 Jan;376(1):17-24.
doi: 10.1515/bchm3.1995.376.1.17.

Bistability and damped oscillations in the fructose 6-phosphate/fructose 1,6-bisphosphate cycle in cell-free extracts from rat liver

J Frenzel  1 , W Schellenberger, K Eschrich
Affiliations

Bistability and damped oscillations in the fructose 6-phosphate/fructose 1,6-bisphosphate cycle in cell-free extracts from rat liver

J Frenzel et al. Biol Chem Hoppe Seyler. 1995 Jan.

Abstract

The dynamics of the fructose 6-phosphate/fructose 1,6-bisphosphate substrate cycle was investigated in cell-free extracts from rat liver. Under conditions of continuous substrate supply different types of stationary states and damped oscillations were observed experimentally and found to be in qualitative agreement with theoretical predictions. Changing the adenylate energy charge of the substrate supply, bistability was shown to be related to irreversible transitions between functionally different branches of stable stationary states.

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