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. 1995 May-Jun;43(2):330-5.
doi: 10.1007/BF00172834.

Characterization of a bacteriocin produced by Streptococcus thermophilus ST134

D J Ward  1 , G A Somkuti
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Characterization of a bacteriocin produced by Streptococcus thermophilus ST134

D J Ward et al. Appl Microbiol Biotechnol. 1995 May-Jun.

Abstract

A pH-dependent adsorption/desorption technique was used to screen Streptococcus thermophilus strains for the production of bacteriocins. Agar-diffusion tests with S. thermophilus strains as targets identified 13 out of 41 strains as producers of antibacterial activity. Thermophilin A, the bacteriocin-like substance present in the culture supernatant of S. thermophilus ST134 was purified to homogeneity by ammonium sulfate precipitation and ion-exchange chromatography, followed by ultrafiltration. Thermophilin A is a relatively heat-stable and apparently glycosylated bacteriocin with a bactericidal mode of action against sensitive cells.

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