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Review
. 1995 Apr;5(2):168-73.
doi: 10.1016/0959-437x(95)80004-2.

Chromatin-mediated transcriptional repression in yeast

S Y Roth  1
Affiliations
Review

Chromatin-mediated transcriptional repression in yeast

S Y Roth. Curr Opin Genet Dev. 1995 Apr.

Abstract

Chromatin is linked to two modes of transcriptional repression in yeast: silencing at the HM loci and telomeres, and repression by the global regulator complex Ssn6/Tup1. In both cases, unique chromatin configurations appear to be orchestrated by multiprotein complexes targeted to particular regions through interactions with specific DNA-binding proteins, such as RAP1, the origin-recognition complex, and alpha 2.

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