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Review
. 1995 Apr;5(2):217-21.
doi: 10.1016/0959-437x(95)80011-5.

TFIIH: a link between transcription, DNA repair and cell cycle regulation

T Seroz  1 , J R Hwang, V Moncollin, J M Egly
Affiliations
Review

TFIIH: a link between transcription, DNA repair and cell cycle regulation

T Seroz et al. Curr Opin Genet Dev. 1995 Apr.

Abstract

TFIIH is a basal transcription factor for protein-coding genes. It contains ERCC2, ERCC3, MO15 and cyclin H, polypeptides implicated in nucleotide excision repair or cell cycle regulation. The dysfunction of TFIIH could result in a large panel of genetic disorders, such as xeroderma pigmentosum, Cockayne's syndrome and trichothiodystrophy. This link between transcription, DNA repair and cell cycle has highlighted a complex and essential role for TFIIH in the cell and has provided much information on the molecular mechanisms of each of these cellular processes.

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