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. 1995 Mar;27(4):312-7.
doi: 10.1007/BF00352099.

The glucose-dependent transactivation activity of ABF1 on the expression of the TDH3 gene in yeast

S Y Jung  1 , H Y Yoo, Y H Kim, J Kim, H M Rho
Affiliations

The glucose-dependent transactivation activity of ABF1 on the expression of the TDH3 gene in yeast

S Y Jung et al. Curr Genet. 1995 Mar.

Abstract

Autonomously replicating sequence binding factor 1 (ABF1) has been implicated in the control of a variety of gene expressions in Saccharomyces cerevisiae. In this paper evidence is presented that ABF1 is involved in the glucose-dependent expression of the TDH3 gene which encodes glyceraldehyde-3-phosphate dehydrogenase. ABF1 binds to consensus sites located between -420 and -250, and between +77 and +200, and acts as a transactivator in an orientation-independent manner on both upstream and downstream sites. TDH3-lacZ fusions having an ABF1 consensus motif showed glucose-dependent expression of TDH3, whereas in the abf1 mutant strain JCA35 glucose-dependent expression disappeared. These findings suggest that ABF1 functions as a glucose-dependent transactivator for the expression of the TDH3 gene.

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References

    1. Mol Cell Biol. 1990 May;10(5):2437-41 - PubMed
    1. Mol Cell Biol. 1990 Sep;10(9):4872-85 - PubMed
    1. Mol Cell Biol. 1992 Mar;12(3):1064-77 - PubMed
    1. Mol Cell Biol. 1990 Feb;10(2):859-62 - PubMed
    1. Nucleic Acids Res. 1988 Aug 11;16(15):7287-301 - PubMed

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