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. 1995 Aug;64(2):285-7.
doi: 10.1016/s0015-0282(16)57724-3.

Hyperprolactinemia after treatment of long-acting gonadotropin-releasing hormone analogue Decapeptyl in girls with central precocious puberty

A Kauschansky  1 , M Nussinovitch, M Frydman, A Yeshaya, Z Ben-Rafael
Affiliations
Free article

Hyperprolactinemia after treatment of long-acting gonadotropin-releasing hormone analogue Decapeptyl in girls with central precocious puberty

A Kauschansky et al. Fertil Steril. 1995 Aug.
Free article

Abstract

Objective: To clarify the effects of prolonged treatment with long-acting GnRH analogue on serum PRL levels.

Design: Blood PRL levels were measured at 9 A.M. every 28 days for a period of 6 months.

Setting: Pediatric Endocrine Clinic, Hasharon Hospital, Petah Tiqva, Israel.

Patients: Thirteen girls with idiopathic central precocious puberty.

Results: Hyperprolactinemia developed in 5 of 13 girls after treatment with long-acting GnRH-a; mean blood PRL in all 13 girls rose significantly from 11.9 +/- 5.6 to 21.5 +/- 12.5 micrograms/L (mean +/- SD).

Conclusions: The mechanism of hyperprolactinemia in our patients is unclear. It may have resulted from a decline in the release of the hypothalamic PRL inhibitory factor. Clinically, transient hyperprolactinemia during long-acting GnRH-a treatment for central precocious puberty also may reflect a constant depression of LH secretion.

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