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. 1995 Aug;63(8):3231-4.
doi: 10.1128/iai.63.8.3231-3234.1995.

T-cell cytokine responses in human infection with Mycobacterium tuberculosis

M Zhang  1 , Y Lin, D V Iyer, J Gong, J S Abrams, P F Barnes
Affiliations

T-cell cytokine responses in human infection with Mycobacterium tuberculosis

M Zhang et al. Infect Immun. 1995 Aug.

Abstract

Compared with healthy tuberculin reactors, Mycobacterium tuberculosis-stimulated peripheral blood mononuclear cells from tuberculosis patients had diminished production and mRNA expression of the Th1 cytokines gamma interferon and interleukin 2 (IL-2), with no change in production and mRNA expression for the Th2 cytokines IL-4, IL-10, and IL-13. These results were confirmed by evaluation of T cells and CD4+ cells. At the level of systemic T cells, development of tuberculosis is associated with diminished Th1 but not enhanced Th2 responses.

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