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Comparative Study
. 1995 Feb;25(2):203-5.
doi: 10.1016/0020-7519(94)00089-7.

Status of hepatic glutathione-S-transferase(s) during Plasmodium berghei infection and chloroquine treatment in Mastomys natalensis

P Srivastava  1 , A J Arif, V C Pandey
Affiliations
Comparative Study

Status of hepatic glutathione-S-transferase(s) during Plasmodium berghei infection and chloroquine treatment in Mastomys natalensis

P Srivastava et al. Int J Parasitol. 1995 Feb.

Abstract

Plasmodium berghei infection in Mastomys natalensis impaired the hepatic mitochondrial, microsomal and cytosolic glutathione-S-transferase(s) activity with 1-chloro-2,4-dinitrobenzene as substrate. The enzyme activity was concomitantly decreased with rise in parasitaemia. The decreased enzyme activity due to infection was almost normalized with oral treatment of 16 mg (kg body wt)-1 of chloroquine for 4 days.

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