Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1995 Aug;15(8):3998-4008.
doi: 10.1128/MCB.15.8.3998.

The essential helicase gene RAD3 suppresses short-sequence recombination in Saccharomyces cerevisiae

A M Bailis  1 , S Maines, M T Negritto
Affiliations

The essential helicase gene RAD3 suppresses short-sequence recombination in Saccharomyces cerevisiae

A M Bailis et al. Mol Cell Biol. 1995 Aug.

Abstract

We have isolated an allele of the essential DNA repair and transcription gene RAD3 that relaxes the restriction against recombination between short DNA sequences in Saccharomyces cerevisiae. Double-strand break repair and gene replacement events requiring recombination between short identical or mismatched sequences were stimulated in the rad3-G595R mutant cells. We also observed an increase in the physical stability of double-strand breaks in the rad3-G595R mutant cells. These results suggest that the RAD3 gene suppresses recombination involving short homologous sequences by promoting the degradation of the ends of broken DNA molecules.

PubMed Disclaimer

References

    1. Genetics. 1989 Dec;123(4):683-94 - PubMed
    1. Proc Natl Acad Sci U S A. 1986 Oct;83(20):7831-5 - PubMed
    1. Cell. 1992 Aug 21;70(4):659-70 - PubMed
    1. Cell. 1993 Oct 22;75(2):341-50 - PubMed
    1. J Theor Biol. 1976 Jun;59(1):97-106 - PubMed

Publication types

MeSH terms

LinkOut - more resources