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Clinical Trial
. 1995 Aug;152(8):1210-2.
doi: 10.1176/ajp.152.8.1210.

Further evidence of a dose-response threshold for haloperidol in psychosis

C K Stone  1 , D L Garve, J Griffith, J Hirschowitz, J Bennett
Affiliations
Clinical Trial

Further evidence of a dose-response threshold for haloperidol in psychosis

C K Stone et al. Am J Psychiatry. 1995 Aug.

Abstract

Objective: The authors' goal was to determine whether higher doses of haloperidol improve antipsychotic response.

Method: During a 2-week, double-blind, randomized fixed-dose study, 24 psychotic patients were given 4, 10, or 40 mg/day of haloperidol.

Results: No clinically relevant difference between groups in favor of the higher antipsychotic doses could be detected.

Conclusions: Doses of 4 mg/day of haloperidol appear to be as effective as higher doses in the treatment of psychosis.

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Comment in

  • Haloperidol dosing strategies.
    Schooler NR. Schooler NR. Am J Psychiatry. 1996 Aug;153(8):1108; author reply 1109. Am J Psychiatry. 1996. PMID: 8678185 No abstract available.
  • Haloperidol dosing strategies.
    Volavka J. Volavka J. Am J Psychiatry. 1996 Aug;153(8):1108; author reply 1109. Am J Psychiatry. 1996. PMID: 8678186 No abstract available.

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