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. 1995 May;39(5):1204-5.
doi: 10.1128/AAC.39.5.1204.

Novel mutation in the UL97 gene of a clinical cytomegalovirus strain conferring resistance to ganciclovir

M N Hanson  1 , L C Preheim, S Chou, C L Talarico, K K Biron, A Erice
Affiliations

Novel mutation in the UL97 gene of a clinical cytomegalovirus strain conferring resistance to ganciclovir

M N Hanson et al. Antimicrob Agents Chemother. 1995 May.

Abstract

Characterization of a ganciclovir-resistant cytomegalovirus strain from a patient with AIDS showed a histidine-to-glutamine change at residue 520 of UL97 (Q520 mutation). In anabolism studies, Q520 was associated with impaired phosphorylation of ganciclovir. Transfer of Q520 to a recombinant virus resulted in a ganciclovir-resistant phenotype.

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