[Experience with other tumors: breast, ovary, brain tumors and sarcomas]

Abstract

High-dose chemotherapy and autologous bone-marrow was widely tested in different solid tumors. This treatment is under investigation in metastatic and high-risk loco-regional breast cancer in France (Pegase protocol). There is few evidence of a role of high-dose chemotherapy in the first line treatment of poor-risk germ cell tumors. However the role of high-dose chemotherapy in the salvage setting of germ tumors is studied in an european randomized trial. At present there is no evidence of the role of this treatment in other solid tumors of adulthood.