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Case Reports
. 1995 Jul 1;82(1):67-9.
doi: 10.1016/0165-4608(94)00223-x.

Translocation (5;19)(q13;q13) in a multinodular thyroid goiter

J C Cigudosa  1 , A Pedrosa Guerra, A Otero Gómez, J L Carrasco Juan, J A Pérez Gómez, O F Ferrer Roca, J L García Miranda
Affiliations
Case Reports

Translocation (5;19)(q13;q13) in a multinodular thyroid goiter

J C Cigudosa et al. Cancer Genet Cytogenet. .

Abstract

We describe the cytogenetics of a multinodular thyroid goiter where 90% of the analyzed cells showed a diploid karyotype with a balanced translocation between chromosomes 5 and 19: 46,XX,t(5;19)(q13;q13). This translocation has been previously described in cases of thyroid adenoma. Our case is the first report of this anomaly in nodular hyperplasia. We discuss its putative role in the neoplastic transformation of thyroid lesions.

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