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. 1995 Jul 17;368(2):331-5.
doi: 10.1016/0014-5793(95)00687-5.

hBD-1: a novel beta-defensin from human plasma

K W Bensch  1 , M Raida, H J Mägert, P Schulz-Knappe, W G Forssmann
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Free article

hBD-1: a novel beta-defensin from human plasma

K W Bensch et al. FEBS Lett. .
Free article

Abstract

We report the isolation and characterization of a novel peptide with significant sequence homology to beta-defensins from human blood filtrate. The human beta-defensin-1 (hBD-1) is a short basic peptide of 36 amino acid residues. It contains six cysteines forming three intramolecular disulfide bonds. The molecular mass of hBD-1 is 3928.6 Da. Cloning of the specific cDNA confirmed the amino acid sequence of the native peptide. hBD-1 shares the nine conserved amino acids characteristic for beta-defensins from respiratory epithelial cells and neutrophils of cattle and chicken leukocytes. hBD-1 is present in nanomolar concentration in human plasma.

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