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. 1995 Apr;84(4):493-8.
doi: 10.1002/jps.2600840420.

Stealth Me.PEG-PLA nanoparticles avoid uptake by the mononuclear phagocytes system

D Bazile  1 , C Prud'homme, M T Bassoullet, M Marlard, G Spenlehauer, M Veillard
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Stealth Me.PEG-PLA nanoparticles avoid uptake by the mononuclear phagocytes system

D Bazile et al. J Pharm Sci. 1995 Apr.

Abstract

Nanoparticles were prepared from methoxy poly(ethylene glycol)poly(d,l-lactic acid) block copolymers (Me.PEG-PLA) or blends of Me.PEG-PLA and PLA by the precipitation-solvent diffusion method. These nanoparticles, labeled by introducing [14C]PLA in the formulation, were shown to be more slowly captured by cultured THP-1 monocytes than F68-coated PLA nanoparticles, in a PEG chain-length-dependent manner. In vivo, the half-life in plasma of the Me.PEG-PLA nanoparticles that were intravenously administered to rats is increased by a factor 180 compared with the F68-coated PLA nanoparticles. This mononuclear phagocytes system avoidance was explained according to a conformation model in which the PEG density at the surface of the particles is a key parameter.

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