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. 1995 Apr;84(4):520-2.
doi: 10.1002/jps.2600840427.

Effect of pH on injection phlebitis

P Simamora  1 , S Pinsuwan, J M Alvarez, P B Myrdal, S H Yalkowsky
Affiliations

Effect of pH on injection phlebitis

P Simamora et al. J Pharm Sci. 1995 Apr.

Abstract

Formulation pH has been reported to be responsible for the incidence of phlebitis. In this study, the effect of pH on injection phlebitis is investigated. Buffers of varying pHs were examined for their ability to produce phlebitis in rabbits. Thermal measurements as well as visual evaluations were used for phlebitis quantitation. The results show that formulation pH between 3.0 and 11.0 does not contribute to the incidence of phlebitis when administered as an iv bolus injection.

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