Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1995 Apr;4(4):501-6.
doi: 10.1093/hmg/4.4.501.

Regulation of insulin gene expression by the IDDM associated, insulin locus haplotype

A M Lucassen  1 , G R Screaton, C Julier, T J Elliott, M Lathrop, J I Bell
Affiliations

Regulation of insulin gene expression by the IDDM associated, insulin locus haplotype

A M Lucassen et al. Hum Mol Genet. 1995 Apr.

Abstract

A 4.1 kb genomic region, spanning the insulin (INS) gene, confers genetic susceptibility to Type 1 or insulin-dependent diabetes mellitus (IDDM). Ten polymorphisms within this region form two predominant, complementary haplotypes. We have been studying the effects of these polymorphisms on the levels of insulin mRNA. Cloned genomic DNA fragments representing these two separate haplotypes were transiently transfected into a rodent pancreatic beta cell line, HIT-T15. These studies revealed that insulin mRNA levels were consistently higher in the transfectants expressing the diabetic haplotype. Over-expression of insulin mRNA may provide the basic mechanism for the diabetic susceptibility encoded at the INS locus.

PubMed Disclaimer

LinkOut - more resources