Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1995 Sep;69(9):5838-42.
doi: 10.1128/JVI.69.9.5838-5842.1995.

High levels of anti-human immunodeficiency virus type 1 (HIV-1) memory cytotoxic T-lymphocyte activity and low viral load are associated with lack of disease in HIV-1-infected long-term nonprogressors

C Rinaldo  1 , X L Huang, Z F Fan, M Ding, L Beltz, A Logar, D Panicali, G Mazzara, J Liebmann, M Cottrill, et al.
Affiliations
Comparative Study

High levels of anti-human immunodeficiency virus type 1 (HIV-1) memory cytotoxic T-lymphocyte activity and low viral load are associated with lack of disease in HIV-1-infected long-term nonprogressors

C Rinaldo et al. J Virol. 1995 Sep.

Abstract

Lack of disease in long-term nonprogressors with human immunodeficiency virus type 1 (HIV-1) infection was strongly associated with very low copy numbers of HIV-1 DNA and RNA in peripheral blood mononuclear cells and plasma and the presence of high levels of anti-HIV-1 CD8+ memory cytotoxic T lymphocytes specific for Gag, Pol, and Env, compared with levels present in intermediate and advanced progressors. CD8+ memory cytotoxic T lymphocytes may have an important role in controlling HIV-1 replication and preventing disease in long-term nonprogressors.

PubMed Disclaimer

References

    1. J Virol. 1994 Jul;68(7):4650-5 - PubMed
    1. J Exp Med. 1991 Dec 1;174(6):1593-600 - PubMed
    1. J Leukoc Biol. 1994 Sep;56(3):328-34 - PubMed
    1. Curr Opin Immunol. 1994 Aug;6(4):553-9 - PubMed
    1. N Engl J Med. 1995 Jan 26;332(4):201-8 - PubMed

Publication types

MeSH terms