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. 1995 Sep;154(3):964-7.
doi: 10.1016/s0022-5347(01)66944-1.

Chromophobe cell renal carcinoma: clinicopathological features of 50 cases

T B Crotty  1 , G M Farrow, M M Lieber
Affiliations

Chromophobe cell renal carcinoma: clinicopathological features of 50 cases

T B Crotty et al. J Urol. 1995 Sep.

Abstract

Purpose: We review the clinicopathological features of chromophobe cell renal carcinoma.

Materials and methods: Cases were identified by reviewing the histology of all renal neoplasms resected between 1977 and 1990. Clinical data were obtained by chart review.

Results: Of 50 cases a majority (53%) were discovered incidentally and most (86%) were stage I. Typical pathological findings included the presence of 2 cell types (pale and eosinophilic), reactivity for Hale's colloidal iron, ultrastructural cytoplasmic vesicles and deoxyribonucleic acid aneuploidy. At last followup 47 patients (94%) were tumor-free or dead of unrelated causes. Survival was similar in patients with clear cell carcinoma of similar grade and stage.

Conclusions: Chromophobe cell carcinoma is a morphologically distinctive neoplasm with a favorable prognosis. Distinction from renal oncocytoma is important.

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