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Clinical Trial
. 1995 Aug 19;346(8973):459-61.
doi: 10.1016/s0140-6736(95)91320-3.

Thromboprophylaxis with low-molecular-weight heparin in outpatients with plaster-cast immobilisation of the leg

H J Kock  1 , K P Schmit-Neuerburg, J Hanke, G Rudofsky, H Hirche
Affiliations
Clinical Trial

Thromboprophylaxis with low-molecular-weight heparin in outpatients with plaster-cast immobilisation of the leg

H J Kock et al. Lancet. .

Abstract

Deep-vein thrombosis is common after plaster-cast immobilisation for traumatic injury. We did a randomised prospective study of the effect of low-molecular-weight heparin on the incidence of deep-vein thrombosis in patients with minor injuries treated with plaster-cast immobilisation of the leg. A control group (n = 163) received no prophylaxis, the prophylaxis group received low-molecular-weight heparin once daily (n = 176). The incidence of deep-vein thrombosis in the prophylaxis group was 0% (one tailed p < 0.006) vs 4.3% in the control group. No severe side-effects of low-molecular-weight heparin were observed. Thromboprophylaxis with low-molecular-weight heparin once daily is effective in reducing the risk of deep-vein thrombosis in outpatients with plaster-cast immobilisation of the leg.

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