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Comparative Study
. 1995 Mar;70(1-2):167-74.
doi: 10.1016/0166-6851(95)00033-w.

Pfcrk-1, a developmentally regulated cdc2-related protein kinase of Plasmodium falciparum

C Doerig  1 , C Doerig, P Horrocks, J Coyle, J Carlton, A Sultan, D Arnot, R Carter
Affiliations
Comparative Study

Pfcrk-1, a developmentally regulated cdc2-related protein kinase of Plasmodium falciparum

C Doerig et al. Mol Biochem Parasitol. 1995 Mar.

Abstract

A gene encoding a novel cdc2-related protein kinase has been identified in Plasmodium falciparum, using degenerate oligonucleotides designed to hybridise to regions that are conserved in members of the cdc2 gene family. This gene, called Pfcrk-1, is located on chromosome 4. It is most closely related to the p58GTA gene family, members of which are negative regulators of cell growth in vertebrates. Pfcrk-1 is developmentally regulated, as indicated by stage-specific accumulation of mRNA in gametocytes.

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